ANTIHYPERLIPIDEMIC DRUGS CLASSIFICATION PDF

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Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Antihyperlipidemic Drugs. Hyperlipidemias. Hyperlipoproteinemias. Hyperlipemia. Hypercholestrolemia. Direct relationship with acute pancreatitis.

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In other projects Wikimedia Commons. Diabetes Mellitus with one of the primary hyperlipidaemias. When these macrophages become overloaded with lipids, they are transformed into distressed foam cells that initiate a local inflammatory response. Share buttons are a little bit lower. Antihyperlipidemic agents What are Antihyperlipidemic agents? Cutaneous flush most classigication side effects accompanied by an uncomfortable feeling of warmth and pruritus.

Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

These drugs are effective in lowering plasma cholesterol levels in all types of hyperlipidemias However, patients who are homozygous for familial hypercholesterolemia lack LDL receptors and, therefore, benefit much less from treatment with these drugs. Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity PowerPoint Presentation: Drugs and Dyslipidemias statins and other lipid and atherosclerosis-modifying drugs October 18, Frank F.

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Considerable evidence points to oxidation of LDL as an essential step in the development of atheromaand therefore interest has centred on the role of either endogenous or therapeutic vitamin E in prevention of atheroma. About project SlidePlayer Terms of Service.

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Published by Agnes Black Modified over 3 years ago. Colesevelam Colestilan Colestipol Colestyramine Colextran. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Lipid-lowering agent

Therapeutic uses Hypertriglyceridemia the most effective in reduction TGs – combined hyperlipidemia type III if statins are contraindicated. Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications.

The sites of action of several antihyperlipidemic drugs are shown. These classes are based on the mechanisms of action of these drugs.

Adverse effect of statins: Define the pharmacophoric requirements of the statin class of antihyperlipidemics. Because of a circadian rhythm to LDL-receptor synthesis, statins are a little more effective if given in the evening rather than in the morning PowerPoint Presentation: By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. In order to view it, please contact the author of the presentation.

Atherosclerosis Focal plaques within the intima containing cholesterol and cholesterol esters CE Affects large and medium sized arteries Causes coronary. Please enter User Name Password Error: Please enter Password Forgot Username? In patients with classofication insufficiency In patients taking drugs such as cyclosporine, itraconazoleerythromycin, gemfibrozilor niacin. Drugs That Help Normalize Cholesterol.

List of Antihyperlipidemic agents – Generics Only –

Omega-3 marine triglycerides Maxepa contain the triglyceride precursors of two polyunsaturated fatty acids derived from oily fish. Lipids, mainly cholesterol and triglycerides, are transported in human plasma by macromolecular complexes termed lipoproteins.

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Excretion takes place through the bile and feces some urinary elimination also occurs. Mechanism of action of statins: They have no place in treating hypercholesterolaemia. Antihtperlipidemic Where hepatic or renal function is severely impaired but anihyperlipidemic has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women.

Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics based on the structure and mode of action Define HMG-CoA and its role in hyperlipidemia Define the pharmacophoric requirements of the statin class of antihyperlipidemics Describe some antihyperlipidemics obtained from fermentation process Describe drkgs cholesterol biosynthetic pathway and its significance Define PPAR?

Adverse effect of statins PowerPoint Presentation: Patients with poor renal Function In patients taking a statin. A formulation of ezetimibe and simvastatin has been shown to lower LDL levels more effectively than the statin alone. Fibrates enhance the effect of co-administered oral Anticoagulants.

Serum VLDL and antihyperlipiemic are increased. Plasma Lipids cholesterol and triglycerides Essential fatty acid linoleic acid and linolenic acid Poly-unsaturated Fatty Acid. The presentation is successfully added In Your Favorites. Patients with moderate to severe hepatic insufficiency should not be treated with ezetimibe.

Colesevelam has fewer gastrointestinal side effects and not Impaired absorptions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Subscribe to free Drugs.